Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model
نویسندگان
چکیده
Citation: Sousa PS, Silva IN, Moreira LM, Veríssimo A and Costa J (2018) Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model. Front. Cell. Infect. Microbiol. 8:97. doi: 10.3389/fcimb.2018.00097 Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model
منابع مشابه
Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
Legionella pneumophila, the causative agent of a severe pneumonia named Legionnaires' disease, is an important human pathogen that infects and replicates within alveolar macrophages. Its virulence depends on the Dot/Icm type IV secretion system (T4SS), which is essential to establish a replication permissive vacuole known as the Legionella containing vacuole (LCV). L. pneumophila infection can ...
متن کاملLegionella pneumophila pathogenesis in the Galleria mellonella infection model.
Legionella pneumophila is a facultative intracellular human pathogen and the etiological agent of severe pneumonia known as Legionnaires' disease. Its virulence depends on protein secretion systems, in particular, the Dot/Icm type IV secretion system (T4SS), which is essential to establish a replication-permissive vacuole in macrophages. The analysis of the role of these systems and their subst...
متن کاملAn Investigation of the Legionella Pneumophila Infection in Pneumonic Patients in Three Different Infections Hospital Wards in Tehran
Legionella pneumophila is one of the causative agent of pneumonia in human being. In recent years many reports has been come from different parts of world regarding infectivity of this organism. This disease occurs almost because of contamination of air conditioning systems. For the purpose of assessment of the legionella pneumophila in pneumonic patients, 200 specimen from sputum and tracheo-b...
متن کاملGalleria mellonella as an infection model to investigate virulence of Vibrio parahaemolyticus
Non-toxigenic V. parahaemolyticus isolates (tdh-/trh-/T3SS2-) have recently been isolated from patients with gastroenteritis. In this study we report that the larvae of the wax moth (Galleria mellonella) are susceptible to infection by toxigenic or non-toxigenic clinical isolates of V. parahaemolyticus. In comparison larvae inoculated with environmental isolates of V. parahaemolyticus did not s...
متن کاملAnti-Legionella dumoffii Activity of Galleria mellonella Defensin and Apolipophorin III
The gram-negative bacterium Legionella dumoffii is, beside Legionella pneumophila, an etiological agent of Legionnaires' disease, an atypical form of pneumonia. The aim of this study was to determine the antimicrobial activity of Galleria mellonella defense polypeptides against L. dumoffii. The extract of immune hemolymph, containing a mixture of defense peptides and proteins, exhibited a do...
متن کامل